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Hydroxychloroquine: small effects in mild disease

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Hydroxychloroquine: small effects in mild disease

• Rachel Levantovsky &
• Nicolas Vabret

Nature Reviews Immunology (2020)Cite this article  

• Published: 14 April 2020
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This preprint reports a double-blind, randomized clinical trial of 62 patients to assess the efficacy of hydroxychloroquine (HCQ) in mild COVID-19. Patients in the treatment arm received 400 mg HCQ per day for 5 days. Fever and cough resolved on average 1 day earlier with HCQ, although the distribution of symptomatic patients at day 0 was not even between groups. No patients receiving HCQ progressed to severe disease, whereas 4 of 31 patients in the control arm progressed. Few clinical data and no viral load measurements were reported, limiting the conclusions that can be drawn from this trial. This study suggests relative efficacy for patients with mild disease and warrants larger clinical trials, but the effects of HCQ on patients with more severe COVID-19 remain unknown.

References


Original article

Chen, Z. et al. Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial. Preprint at medRxiv https://doi.org/10.1101/2020.03.22.20040758 (2020)
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1. Sinai Immunology Review Project, Icahn School of Medicine at Mount Sinai, New York, NY, USA
   • Rachel Levantovsky
   • & Nicolas Vabret

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Correspondence to Rachel Levantovsky or Nicolas Vabret.[/p][p]

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The authors declare no competing interests.

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Levantovsky, R., Vabret, N. Hydroxychloroquine: small effects in mild disease. Nat Rev Immunol (2020). https://doi.org/10.1038/s41577-020-0315-4
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• Published14 April 2020
• DOI https://doi.org/10.1038/s41577-020-0315-4

https://www.nature.com/articles/s41577-020-0315-4